Mechanism

Corticotropin-releasing factor receptor signalling

Activation of corticotropin-releasing factor receptors by urocortin-family peptides.

Use for native urocortin where both CRF1 and CRF2 receptor activity are relevant.

Biological pathway

Urocortin can activate CRF1 and CRF2 receptors, increasing cyclic AMP and influencing stress responses, appetite, vascular tone and cardiac function.

00b

Receptor pharmacology is well established, and controlled human infusion studies demonstrate acute endocrine and haemodynamic effects.

00c

Effects differ by receptor subtype, tissue, dose and infusion duration; acute target engagement does not establish long-term therapeutic benefit.

An endogenous CRF-family peptide involved in stress, appetite, endocrine and cardiovascular signalling.

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from the knowledge graph

Peptides that touch this

Conditions in scope