HPG axis modulation
The hypothalamic-pituitary-gonadal axis regulates reproductive hormone secretion and function.
Biological pathway
Kisspeptin activates KISS1R on GnRH neurons, increasing GnRH and downstream LH/FSH signalling.
Evidence summary
Kisspeptin has strong mechanistic and reproductive endocrinology evidence, with early human research in sexual desire.
Limitations
Peptides linked to this mechanism
Oxytocin is an endogenous signalling peptide with physiological relevance; therapeutic administration remains molecule- and indication-specific.
Kisspeptin is an endogenous signalling peptide with physiological relevance; therapeutic administration remains molecule- and indication-specific.
Neurokinin B is an endogenous signalling peptide with physiological relevance; therapeutic administration remains molecule- and indication-specific.
Phoenixin is an endogenous signalling peptide with established or emerging physiological relevance.