MGF E-domain cell response
Synthetic peptides derived from the E-domain of the IGF-1Ec splice variant have been investigated for effects on progenitor-cell proliferation, survival, migration and differentiation.
Biological pathway
Synthetic MGF E-domain peptide exposure → incompletely defined receptor or membrane interaction → context-dependent changes in progenitor-cell proliferation, survival and differentiation.
Evidence summary
Some cell and animal studies report biological activity, but other laboratories have failed to reproduce key muscle-cell findings and the endogenous existence of a freely circulating MGF E-peptide remains disputed.
Limitations
Peptides linked to this mechanism
PEG-MGF is an investigational peptide, analogue or research construct with evidence ranging from mechanistic studies to limited human trials.
MGF is an investigational peptide, analogue or research construct with evidence ranging from mechanistic studies to limited human trials.