Cardiovascular and Renal
Natriuretic peptide receptor-A signalling
Activation of particulate guanylyl cyclase-A by atrial natriuretic peptide.
Biological pathway
Receptor activation raises intracellular cyclic GMP, promoting natriuresis, diuresis, vasodilation and suppression of renin-aldosterone signalling.
Evidence summary
The physiology is well established in humans, while therapeutic manipulation is product- and indication-specific.
Limitations
Rapid degradation, blood-pressure effects and renal-state dependence limit generalisation from physiology to treatment.