Sensory neuropeptide modulation
Modulation of sensory-neuron signalling and neurogenic inflammatory mediators associated with skin discomfort.
Biological pathway
Reduced release or action of calcitonin gene-related peptide and altered neuronal excitability are proposed to raise the threshold for irritation-related sensations.
Evidence summary
Review literature describes acetyl tetrapeptide-15 as a cosmetic soothing peptide supported mainly by supplier-associated in vitro and small in vivo studies.
Limitations
Peptides linked to this mechanism
Calcitonin Gene-Related Peptide is an endogenous peptide with established physiological or receptor-level biology; therapeutic administration and indications are molecule-specific.
Neurokinin B is an endogenous signalling peptide with physiological relevance; therapeutic administration remains molecule- and indication-specific.
Substance P is an endogenous signalling peptide with established or emerging physiological relevance.
A topical cosmetic peptide marketed to reduce skin discomfort and hyperreactivity. Evidence is preliminary and largely supplier-associated.
Neurokinin A is an endogenous signalling peptide with physiological relevance; therapeutic administration remains molecule- and indication-specific.