Dermatology
Sensory neuropeptide modulation
Modulation of sensory-neuron signalling and neurogenic inflammatory mediators associated with skin discomfort.
Biological pathway
Reduced release or action of calcitonin gene-related peptide and altered neuronal excitability are proposed to raise the threshold for irritation-related sensations.
Evidence summary
Review literature describes acetyl tetrapeptide-15 as a cosmetic soothing peptide supported mainly by supplier-associated in vitro and small in vivo studies.
Limitations
Independent replication is limited and the pathway does not establish treatment efficacy for neuropathic pain or inflammatory skin disease.