Condition · Metabolic
Weight management
Body weight and composition.
01
Evidence-ranked peptides
| Peptide | Use | Evidence |
|---|---|---|
| Xenin An endogenous gastrointestinal peptide involved in motility, gastric emptying and incretin-linked metabolic signalling. | Weight management weak | Human3/5 Animal0/5 Safety0/5 2 verified refs |
| Urocortin-III An endogenous CRF2-selective peptide studied for vascular, cardiac, metabolic and stress-related physiology. | Weight management insufficient | Human3/5 Animal0/5 Safety2/5 2 verified refs |
| Urocortin An endogenous CRF-family peptide involved in stress, appetite, endocrine and cardiovascular signalling. | Weight management insufficient | Human2/5 Animal0/5 Safety2/5 2 verified refs |
| Cagrilintide Cagrilintide is an investigational peptide, analogue or research construct with evidence ranging from mechanistic studies to limited human trials. | Weight management weak | Human2/5 Animal0/5 Safety2/5 1 verified ref |
| Obestatin Obestatin is an endogenous signalling peptide with physiological relevance; therapeutic administration remains molecule- and indication-specific. | Weight management insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Peptide YY Peptide YY is an endogenous signalling peptide with established or emerging physiological relevance. | Weight management insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
02
Current standard management
conventional medicineEvidence-based non-peptide options — including exercise, sleep, nutrition, physiotherapy and licensed medical treatments — often have stronger human evidence than research peptides.
Medical disclaimer —Standard-of-care information is educational only. Do not change or start treatment based on Atlas content. Always consult a qualified clinician for personal medical decisions.
04
Linked mechanisms
biological pathways discussed for this condition- Amylin receptor signallinglimited
- Ghrelin receptor signallinglimited
- Gut barrier integritylimited
- Corticotropin-releasing factor receptor signallinglimited
- Xenin and neurotensin receptor signallinglimited
03
Community observations
No approved community reports for this condition yet. Submit one.
Clinician discussion
Questions you can ask a qualified clinician
- What are the established evidence-based options for this condition?
- What monitoring is appropriate before considering any experimental intervention?
- What long-term safety data exists for peptide-based approaches?
- Are there licensed medicines relevant to my situation?
↳
Explore further
from the knowledge graphPeptides that touch this
Mechanisms in play
- Gut barrier integrity2 shared
- Ghrelin receptor signalling1 shared
- Corticotropin-releasing factor receptor signalling1 shared
- Sleep homeostasis and neuropeptide signalling1 shared
- Xenin and neurotensin receptor signalling1 shared
- Amylin receptor signalling1 shared
- Corticotropin-releasing factor type 2 receptor signalling1 shared