Sleep homeostasis and neuropeptide signalling
Sleep timing and architecture are regulated by homeostatic, circadian and neurochemical systems.
Biological pathway
DSIP was proposed as a sleep-associated peptide, but no definitive receptor, gene or coherent physiological pathway has been established.
Evidence summary
Older small human studies reported mixed sleep effects, while later reviews considered the sleep-factor hypothesis weak and unresolved.
Limitations
Peptides linked to this mechanism
Neuropeptide Y is an endogenous signalling peptide with physiological relevance; therapeutic administration remains molecule- and indication-specific.
DSIP is an investigational peptide, analogue or research construct with evidence ranging from mechanistic studies to limited human trials.
Orexin is an endogenous signalling peptide with physiological relevance; therapeutic administration remains molecule- and indication-specific.
An endogenous CRF-family peptide involved in stress, appetite, endocrine and cardiovascular signalling.
Epithalamin is an investigational peptide, analogue or research construct with evidence ranging from mechanistic studies to limited human trials.