Sleep Biology
Sleep homeostasis and neuropeptide signalling
Sleep timing and architecture are regulated by homeostatic, circadian and neurochemical systems.
Biological pathway
DSIP was proposed as a sleep-associated peptide, but no definitive receptor, gene or coherent physiological pathway has been established.
Evidence summary
Older small human studies reported mixed sleep effects, while later reviews considered the sleep-factor hypothesis weak and unresolved.
Limitations
The biological identity and physiological role of DSIP remain uncertain.