Nitric oxide / blood flow

An endogenous renin-angiotensin-system peptide with vasodilatory, anti-inflammatory and antifibrotic actions in experimental models. Therapeutic administration remains investigational.

An endogenous peptide associated with substrate use, endothelial function and cardiometabolic health. Most therapeutic claims remain preclinical.

Calcitonin Gene-Related Peptide is an endogenous peptide with established physiological or receptor-level biology; therapeutic administration and indications are molecule-specific.

C-Peptide is an endogenous peptide with established physiological or receptor-level biology; therapeutic administration and indications are molecule-specific.

An endogenous cardiac peptide that promotes natriuresis, vasodilation and suppression of the renin-aldosterone system.

A 28-amino-acid endogenous neuropeptide that activates VPAC receptors and regulates vascular, pulmonary, gastrointestinal, neural and immune functions.

Relaxin 2 is an endogenous signalling peptide with established or emerging physiological relevance.

Intermedin is an endogenous signalling peptide with physiological relevance; therapeutic administration remains molecule- and indication-specific.

A potent endogenous apelin-receptor agonist studied for acute cardiovascular and renal effects.

A synthetic Lys-Glu-Asp tripeptide promoted for vascular bioregulation, with limited and regionally concentrated evidence.

A short endogenous angiotensin fragment studied mainly for learning, memory, cerebral blood flow and insulin-regulated aminopeptidase biology.

A class of engineered natriuretic peptides designed to activate guanylyl cyclase-A and promote vasodilation, natriuresis and blood-pressure reduction.

An endogenous 52-amino-acid peptide hormone involved in vascular tone, endothelial integrity, lymphatic biology and inflammatory responses.

A CRF2-selective endogenous peptide investigated for cardiovascular, heart-failure and skeletal-muscle effects.

An endogenous CRF2-selective peptide studied for vascular, cardiac, metabolic and stress-related physiology.